File → Save ( Ctrl+S ): Save your drawing to a file.

File → Save As... ( Shift+Ctrl+S ): Save your drawing to a file with a new name.

The Save As dialog includes a folder for Inkscape templates under the name templates. Saving a drawing with the name default.svg in this directory will replace the default template (the file opened when Ctrl+N is used). Saving in this directory under a different name will add the file as a template in the File → New From Template... ( Ctrl+Alt+N ) dialog.

An option under the Input/Output tab of the Inkscape Preferences dialog allows one to choose between opening the Save As dialog with the directory set to the same directory as that for the current open document or to the last directory where a file was saved using the dialog.

File → Save a Copy... ( Shift+Ctrl+Alt+S ): Save your drawing to a file with a new name but keep the old file name (and type) for future saves.